BDBM50202088 CHEMBL218142::N-adamantan-2-yl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetamide

SMILES: FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)NC2C3CC4CC(C3)CC2C4)CC1

InChI Key: InChIKey=VYMYQEBDEJHMBR-UHFFFAOYSA-N

Data: 2 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50202088   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50202088 (CHEMBL218142 | N-adamantan-2-yl-2-[4-(5-trifluorom...) Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)NC2C3CC4CC(C3)CC2C4)CC1 |TLB:24:23:27:20.19.18,24:19:22.23.25:27,THB:18:19:22:25.26.27,18:26:22:20.24.19,17:18:22.23.25:27,(8.07,-13.61,;6.75,-12.84,;5.97,-14.17,;7.54,-11.52,;5.43,-12.05,;4.08,-12.79,;2.76,-12,;2.8,-10.46,;4.14,-9.71,;5.45,-10.5,;1.48,-9.67,;.16,-10.46,;-1.18,-9.72,;-1.21,-8.17,;-2.58,-7.47,;-3.88,-8.3,;-3.8,-9.84,;-5.25,-7.6,;-6.54,-8.44,;-6.57,-9.97,;-7.97,-10.3,;-9.29,-9.79,;-10.5,-11.05,;-9,-10.65,;-7.6,-11.23,;-8.98,-9.07,;-7.93,-7.84,;-9.28,-8.31,;.1,-7.38,;1.45,-8.12,)| Show InChI InChI=1S/C22H29F3N4O/c23-22(24,25)18-1-2-19(26-12-18)29-5-3-28(4-6-29)13-20(30)27-21-16-8-14-7-15(10-16)11-17(21)9-14/h1-2,12,14-17,21H,3-11,13H2,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in E. coli by SPA				J Med Chem 50: 149-64 (2007) Article DOI: 10.1021/jm0609364 BindingDB Entry DOI: 10.7270/Q2Z60NQN
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50202088 (CHEMBL218142 | N-adamantan-2-yl-2-[4-(5-trifluorom...) Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)NC2C3CC4CC(C3)CC2C4)CC1 |TLB:24:23:27:20.19.18,24:19:22.23.25:27,THB:18:19:22:25.26.27,18:26:22:20.24.19,17:18:22.23.25:27,(8.07,-13.61,;6.75,-12.84,;5.97,-14.17,;7.54,-11.52,;5.43,-12.05,;4.08,-12.79,;2.76,-12,;2.8,-10.46,;4.14,-9.71,;5.45,-10.5,;1.48,-9.67,;.16,-10.46,;-1.18,-9.72,;-1.21,-8.17,;-2.58,-7.47,;-3.88,-8.3,;-3.8,-9.84,;-5.25,-7.6,;-6.54,-8.44,;-6.57,-9.97,;-7.97,-10.3,;-9.29,-9.79,;-10.5,-11.05,;-9,-10.65,;-7.6,-11.23,;-8.98,-9.07,;-7.93,-7.84,;-9.28,-8.31,;.1,-7.38,;1.45,-8.12,)| Show InChI InChI=1S/C22H29F3N4O/c23-22(24,25)18-1-2-19(26-12-18)29-5-3-28(4-6-29)13-20(30)27-21-16-8-14-7-15(10-16)11-17(21)9-14/h1-2,12,14-17,21H,3-11,13H2,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPA				J Med Chem 50: 149-64 (2007) Article DOI: 10.1021/jm0609364 BindingDB Entry DOI: 10.7270/Q2Z60NQN
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50202088 (CHEMBL218142 | N-adamantan-2-yl-2-[4-(5-trifluorom...) Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)NC2C3CC4CC(C3)CC2C4)CC1 |TLB:24:23:27:20.19.18,24:19:22.23.25:27,THB:18:19:22:25.26.27,18:26:22:20.24.19,17:18:22.23.25:27,(8.07,-13.61,;6.75,-12.84,;5.97,-14.17,;7.54,-11.52,;5.43,-12.05,;4.08,-12.79,;2.76,-12,;2.8,-10.46,;4.14,-9.71,;5.45,-10.5,;1.48,-9.67,;.16,-10.46,;-1.18,-9.72,;-1.21,-8.17,;-2.58,-7.47,;-3.88,-8.3,;-3.8,-9.84,;-5.25,-7.6,;-6.54,-8.44,;-6.57,-9.97,;-7.97,-10.3,;-9.29,-9.79,;-10.5,-11.05,;-9,-10.65,;-7.6,-11.23,;-8.98,-9.07,;-7.93,-7.84,;-9.28,-8.31,;.1,-7.38,;1.45,-8.12,)| Show InChI InChI=1S/C22H29F3N4O/c23-22(24,25)18-1-2-19(26-12-18)29-5-3-28(4-6-29)13-20(30)27-21-16-8-14-7-15(10-16)11-17(21)9-14/h1-2,12,14-17,21H,3-11,13H2,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIA				J Med Chem 50: 149-64 (2007) Article DOI: 10.1021/jm0609364 BindingDB Entry DOI: 10.7270/Q2Z60NQN
					More data for this Ligand-Target Pair