BindingDB PrimarySearch

BDBM50202737 CHEMBL395665::N-(4-(4-amino-7-(3-((1r,4r)-4-aminocyclohexylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

SMILES: COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@H]3CC[C@H](N)CC3)cnc(N)c12

InChI Key: InChIKey=FRQGIFZNGIECRT-LSKJDRFGSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50202737
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.97E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Src				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fgr (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Fgr				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Lyn				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Fyn				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Lck				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Hck				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50202737 (CHEMBL395665 \| N-(4-(4-amino-7-(3-((1r,4r)-4-amino...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Tie2				Bioorg Med Chem Lett 17: 1167-71 (2007) Article DOI: 10.1016/j.bmcl.2006.12.035 BindingDB Entry DOI: 10.7270/Q24Q7TN6
Abbott Bioresearch Center Curated by ChEMBL					More data for this Ligand-Target Pair