null

SMILES: COc1ccccc1N1CCN(Cc2ccc(C)c(c2)-c2ccccc2OC)CC1

InChI Key: InChIKey=WTFGXOKFZFZQTP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50204674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50204674 (CHEMBL3892079) Show SMILES COc1ccccc1N1CCN(Cc2ccc(C)c(c2)-c2ccccc2OC)CC1 Show InChI InChI=1S/C26H30N2O2/c1-20-12-13-21(18-23(20)22-8-4-6-10-25(22)29-2)19-27-14-16-28(17-15-27)24-9-5-7-11-26(24)30-3/h4-13,18H,14-17,19H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...				Eur J Med Chem 123: 180-190 (2016) Article DOI: 10.1016/j.ejmech.2016.07.029 BindingDB Entry DOI: 10.7270/Q27D2X36
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50204674 (CHEMBL3892079) Show SMILES COc1ccccc1N1CCN(Cc2ccc(C)c(c2)-c2ccccc2OC)CC1 Show InChI InChI=1S/C26H30N2O2/c1-20-12-13-21(18-23(20)22-8-4-6-10-25(22)29-2)19-27-14-16-28(17-15-27)24-9-5-7-11-26(24)30-3/h4-13,18H,14-17,19H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins fol...				Eur J Med Chem 123: 180-190 (2016) Article DOI: 10.1016/j.ejmech.2016.07.029 BindingDB Entry DOI: 10.7270/Q27D2X36
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50204674 (CHEMBL3892079) Show SMILES COc1ccccc1N1CCN(Cc2ccc(C)c(c2)-c2ccccc2OC)CC1 Show InChI InChI=1S/C26H30N2O2/c1-20-12-13-21(18-23(20)22-8-4-6-10-25(22)29-2)19-27-14-16-28(17-15-27)24-9-5-7-11-26(24)30-3/h4-13,18H,14-17,19H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins fol...				Eur J Med Chem 123: 180-190 (2016) Article DOI: 10.1016/j.ejmech.2016.07.029 BindingDB Entry DOI: 10.7270/Q27D2X36
					More data for this Ligand-Target Pair