BDBM50204699 4-(6-((4-hydroxypiperidin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzamide::CHEMBL243188

SMILES: NC(=O)c1ccc(cc1)-c1n[nH]c-2c1Cc1cc(CN3CCC(O)CC3)ccc-21

InChI Key: InChIKey=GKEQRQQVZCWXMU-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50204699   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50204699 (4-(6-((4-hydroxypiperidin-1-yl)methyl)-1,4-dihydro...) Show SMILES NC(=O)c1ccc(cc1)-c1n[nH]c-2c1Cc1cc(CN3CCC(O)CC3)ccc-21 Show InChI InChI=1S/C23H24N4O2/c24-23(29)16-4-2-15(3-5-16)21-20-12-17-11-14(1-6-19(17)22(20)26-25-21)13-27-9-7-18(28)8-10-27/h1-6,11,18,28H,7-10,12-13H2,(H2,24,29)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of recombinant CHK1 assessed as human Cdc25C phosphorylation				Bioorg Med Chem 15: 2759-67 (2007) Article DOI: 10.1016/j.bmc.2007.01.012 BindingDB Entry DOI: 10.7270/Q2XS5V22
					More data for this Ligand-Target Pair