BDBM50205140 CHEMBL3946811

SMILES: COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1

InChI Key: InChIKey=WDAHGVLBPINGHW-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50205140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of FLT3 (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-Kit (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	141	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of Ron (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair