BDBM50205274 CHEMBL426387::[(3R)-5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

SMILES: OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21

InChI Key: InChIKey=XSQAICBCYIFUQS-GFCCVEGCSA-N

Data: 8 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50205274   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostanoid TP receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human TP receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostanoid DP receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human DP receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostanoid IP receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human IP receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human EP2 receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human EP3 receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human EP1 receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostaglandin F2-alpha receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Binding affinity to human FP receptor expressed in HEK293 cells				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostanoid TP receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Activity at human TP receptor in platelet rich plasma assessed as inhibition U44619-induced platelet aggregation				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostanoid DP receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Activity at human DP receptor in platelet rich plasma assessed as inhibition of PGD2-induced cAMP accumulation				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair
Prostanoid DP receptor (Homo sapiens (Human))	BDBM50205274 (CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...) Show SMILES OC(=O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 Show InChI InChI=1S/C20H16BrClFNO2/c21-17-9-14(23)8-16-15-6-3-12(7-18(25)26)19(15)24(20(16)17)10-11-1-4-13(22)5-2-11/h1-2,4-5,8-9,12H,3,6-7,10H2,(H,25,26)/t12-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada & Co. Curated by ChEMBL					Assay Description Activity at human DP receptor in washed platelets assessed as inhibition of PGD2-induced cAMP accumulation				J Med Chem 50: 794-806 (2007) Article DOI: 10.1021/jm0603668 BindingDB Entry DOI: 10.7270/Q20P0ZP2
					More data for this Ligand-Target Pair