BDBM50205604 CHEMBL3907401

SMILES: COc1ccc(cc1OC)C1=NN(Cc2ccc(F)cc2)C(=O)CCC1

InChI Key: InChIKey=RKJZOYRJGIPFLH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50205604   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50205604 (CHEMBL3907401) Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(F)cc2)C(=O)CCC1 |t:11| Show InChI InChI=1S/C20H21FN2O3/c1-25-18-11-8-15(12-19(18)26-2)17-4-3-5-20(24)23(22-17)13-14-6-9-16(21)10-7-14/h6-12H,3-5,13H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay				Bioorg Med Chem Lett 27: 24-29 (2017) Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333
					More data for this Ligand-Target Pair