BDBM50205640 CHEMBL3901407
SMILES: Cc1cc(C)c(CNC(=O)c2cc(cc3N(CCc23)C2CCCC2)C#N)c(=O)[nH]1
InChI Key: InChIKey=WEWUYFKALGFFAR-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM50205640 (CHEMBL3901407) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 571 | n/a | n/a | n/a | n/a | n/a | n/a |
Integral BioSciences Pvt. Ltd. Curated by ChEMBL | Assay Description Inhibition of human wild type EZH2 using histone H3 as substrate after 1 hr in presence of 3H-SAM by filter paper detection analysis | Bioorg Med Chem Lett 27: 217-222 (2017) Article DOI: 10.1016/j.bmcl.2016.11.080 BindingDB Entry DOI: 10.7270/Q2S46TZW | |||||||||||
More data for this Ligand-Target Pair |