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BDBM50205744 (2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(3-carbamimidamidopropyl)-8-(1H-indol-3-ylmethyl)-2-(naphthalen-2-ylmethyl)-3,6,9,17,20,31-hexaoxo-1,4,7,10,16,21-hexaazatricyclo[20.8.1.0^{24,29}]hentriaconta-24(29),25,27-triene-11-carboxamide::CHEMBL391704

SMILES: CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O

InChI Key: InChIKey=QUNJOVXJJGQTDV-JREFWSLKSA-N

Data: 4 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50205744   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Effect on human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulation

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
PDB

KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Effect on human MC4R expressed in HEK293 cells assessed as intracellular cAMP accumulation

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Effect on human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulation

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
UniProtKB/SwissProt

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n/an/a 87n/an/an/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]NDPalphaMSH from human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
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n/an/an/an/a>2.50E+3n/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]NDPalphaMSH from human MC1R expressed in HEK293 cells

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50205744
PNG
((2R,5S,8S,11S,19S)-19-[(2S)-2-aminohexanamido]-5-(...)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O)C(N)=O |wU:36.38,9.8,wD:47.49,22.22,18.80,4.4,(-4.16,-15.01,;-2.68,-14.61,;-2.28,-13.13,;-.79,-12.73,;-.39,-11.24,;-1.48,-10.15,;1.1,-10.85,;2.19,-11.94,;1.5,-9.36,;2.99,-8.96,;2.59,-10.45,;3.88,-11.29,;3.95,-12.82,;5.07,-10.33,;4.53,-8.89,;5.34,-7.65,;6.91,-7.66,;7.71,-6.32,;9.25,-6.36,;10.05,-5,;9.29,-3.64,;10.06,-2.32,;7.74,-3.63,;8.5,-2.29,;9.59,-1.19,;11.12,-1.42,;11.81,-.04,;10.72,1.04,;10.79,2.57,;9.5,3.41,;8.13,2.7,;8.06,1.17,;9.35,.34,;7,-2.36,;5.46,-2.34,;4.69,-3.67,;4.69,-1,;5.47,.32,;4.7,1.66,;5.47,2.99,;4.7,4.32,;5.47,5.65,;4.7,6.99,;7.01,5.65,;3.15,-1.01,;2.36,-2.34,;3.11,-3.67,;.82,-2.32,;.07,-.98,;-1.47,-.96,;-2.24,-2.27,;-3.78,-2.26,;-4.54,-.91,;-6.07,-.9,;-6.83,.43,;-6.05,1.77,;-4.51,1.76,;-3.75,.42,;-2.21,.39,;-.14,-3.51,;-1.66,-3.22,;-2.83,-4.23,;-4.2,-3.53,;-5.51,-4.36,;-5.43,-5.91,;-4.06,-6.61,;-2.76,-5.78,;-1.51,-6.7,;-.02,-6.3,;.73,-7.64,;2.21,-7.6,;2.96,-6.26,;.59,-4.88,;2.3,-5,;10,-7.7,;9.21,-9.02,;11.54,-7.73,)|
Show InChI InChI=1S/C56H71N13O8/c1-2-3-18-40(57)50(72)66-45-30-48(70)61-24-11-10-20-42(49(58)71)64-52(74)44(29-38-31-63-41-19-9-8-17-39(38)41)67-51(73)43(21-12-25-62-56(59)60)65-54(76)47(27-33-22-23-34-13-4-5-14-35(34)26-33)69-32-37-16-7-6-15-36(37)28-46(55(69)77)68-53(45)75/h4-9,13-17,19,22-23,26,31,40,42-47,63H,2-3,10-12,18,20-21,24-25,27-30,32,57H2,1H3,(H2,58,71)(H,61,70)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H,68,75)(H4,59,60,62)/t40-,42-,43-,44-,45-,46?,47+/m0/s1
PDB

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n/an/a 580n/an/an/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]NDPalphaMSH from human MC1R expressed in HEK293 cells

Bioorg Med Chem Lett 17: 2492-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.020
BindingDB Entry DOI: 10.7270/Q2FN15W9
More data for this
Ligand-Target Pair