BDBM50205876 (R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol -6(2H)-one::CHEMBL374660
SMILES: CCOc1cc2[C@@H]3CNCCN3C(=O)c2c(c1)C(F)(F)F
InChI Key: InChIKey=TZKSZKXRXZYQGH-NSHDSACASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50205876 ((R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells | J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50205876 ((R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells | J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50205876 ((R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells | J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50205876 ((R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50205876 ((R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50205876 ((R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8 | |||||||||||
More data for this Ligand-Target Pair |