BDBM50205901 (R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one::CHEMBL220900

SMILES: Clc1ccc2[C@@H]3CNCCN3C(=O)c2c1Cl

InChI Key: InChIKey=LGWMDPQPQYEPII-QMMMGPOBSA-N

Data: 3 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205901   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205901 ((R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-...) Show SMILES Clc1ccc2[C@@H]3CNCCN3C(=O)c2c1Cl Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-6-8-5-14-3-4-15(8)11(16)9(6)10(7)13/h1-2,8,14H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205901 ((R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-...) Show SMILES Clc1ccc2[C@@H]3CNCCN3C(=O)c2c1Cl Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-6-8-5-14-3-4-15(8)11(16)9(6)10(7)13/h1-2,8,14H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205901 ((R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-...) Show SMILES Clc1ccc2[C@@H]3CNCCN3C(=O)c2c1Cl Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-6-8-5-14-3-4-15(8)11(16)9(6)10(7)13/h1-2,8,14H,3-5H2/t8-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	383	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205901 ((R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-...) Show SMILES Clc1ccc2[C@@H]3CNCCN3C(=O)c2c1Cl Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-6-8-5-14-3-4-15(8)11(16)9(6)10(7)13/h1-2,8,14H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	57	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205901 ((R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-...) Show SMILES Clc1ccc2[C@@H]3CNCCN3C(=O)c2c1Cl Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-6-8-5-14-3-4-15(8)11(16)9(6)10(7)13/h1-2,8,14H,3-5H2/t8-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205901 ((R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-...) Show SMILES Clc1ccc2[C@@H]3CNCCN3C(=O)c2c1Cl Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-6-8-5-14-3-4-15(8)11(16)9(6)10(7)13/h1-2,8,14H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair