Found 13 hits for monomerid = 50206007 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| PDB Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serine |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
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| PDB Article PubMed
| 156 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot... |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sorbitol dehydrogenase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition sorbitol dehydrogenase by spectrophotometric analysis |
Bioorg Med Chem Lett 20: 5630-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.038 BindingDB Entry DOI: 10.7270/Q28052TK |
More data for this Ligand-Target Pair | |
D-Aspartate Oxidase (DDO)
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.58E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assa... |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
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Similars
| PDB Article PubMed
| n/a | n/a | 943 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assay |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO at 496 nm spectral modification by spectrophotometric analysis in presence of FAD |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aldose reductase (AR)
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis |
Bioorg Med Chem Lett 20: 5630-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.038 BindingDB Entry DOI: 10.7270/Q28052TK |
More data for this Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by stopped flow spectrophotometric analysis in presence of FAD |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serine |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Xanthine dehydrogenase/oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.31E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Modena e Reggio Emilia
Curated by ChEMBL
| Assay Description Inhibition of xanthine oxidase |
Eur J Med Chem 42: 1028-31 (2007)
Article DOI: 10.1016/j.ejmech.2006.12.023 BindingDB Entry DOI: 10.7270/Q2DR2V58 |
More data for this Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO at 443 nm spectral modification by spectrophotometric analysis in presence of FAD |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine racemase
(Homo sapiens (Human)) | BDBM50206007
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mi... |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | |