BindingDB PrimarySearch

BDBM50206160 CHEMBL245621::Halopemide::Halopemide, 8::N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-fluorobenzamide::N-(2-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-fluorobenzamide::cid_65490

SMILES: Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O

InChI Key: InChIKey=NBHPRWLFLUBAIE-UHFFFAOYSA-N

Data: 13 IC50 2 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50206160
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	37
Vanderbilt University					Assay Description PLD in vitro enzymatic assay using phospholipase D1(PLD1).				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 (unknown origin)				Bioorg Med Chem Lett 28: 3670-3673 (2018) Article DOI: 10.1016/j.bmcl.2018.10.033
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	37
Vanderbilt University					Assay Description Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	37
Vanderbilt University					Assay Description cell-based assay using human non-small-cell lung cancer cell line, Calu-1				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	37
Vanderbilt University					Assay Description cell-based assay using HEK293-gfpPLD2 cell line				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D2 (PLD2) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay					Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q21R6P4V
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay					Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2NK3CNK
					More data for this Ligand-Target Pair
Phospholipase D2 (PLD2) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PLD2				Bioorg Med Chem Lett 17: 2310-1 (2007) Article DOI: 10.1016/j.bmcl.2007.01.059 BindingDB Entry DOI: 10.7270/Q21G0KXW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human PLD1 in Calu1 cells				Bioorg Med Chem Lett 19: 1916-20 (2009) Article DOI: 10.1016/j.bmcl.2009.02.057 BindingDB Entry DOI: 10.7270/Q2VM4C5W
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase D2 (PLD2) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of GFP-labelled human PLD2 HEK293 cells				Bioorg Med Chem Lett 19: 1916-20 (2009) Article DOI: 10.1016/j.bmcl.2009.02.057 BindingDB Entry DOI: 10.7270/Q2VM4C5W
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 (unknown origin)				J Med Chem 56: 2695-9 (2013) Article DOI: 10.1021/jm301782e BindingDB Entry DOI: 10.7270/Q2RJ4KT8
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase D2 (PLD2) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD2 (unknown origin)				J Med Chem 56: 2695-9 (2013) Article DOI: 10.1021/jm301782e BindingDB Entry DOI: 10.7270/Q2RJ4KT8
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine receptor D2 (unknown origin)				J Med Chem 56: 2695-9 (2013) Article DOI: 10.1021/jm301782e BindingDB Entry DOI: 10.7270/Q2RJ4KT8
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase D2 (PLD2) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD2 (unknown origin)				Bioorg Med Chem Lett 28: 3670-3673 (2018) Article DOI: 10.1016/j.bmcl.2018.10.033
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM50206160 (CHEMBL245621 \| Halopemide \| Halopemide, 8 \| N-(2-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	37
Vanderbilt University					Assay Description PLD in vitro enzymatic assay using phospholipase D2(PLD2).				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair