BDBM50206427 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid)::AMI-1::CHEMBL221047
SMILES: Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(O)(=O)=O)ccc12)S(O)(=O)=O
InChI Key: InChIKey=PCGISRHGYLRXSR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of human GST-tagged PRMT1-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using H4(1-20) and [14C]-AdoMet by scinti... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.76E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of His6x-tagged PRMT1-mediated protein arginine methylation expressed in Escherichia coli BL21 (DE3) using GAR R4 peptide and [14C]-AdoMet... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase p300 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.19E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of HAT p300-mediated arginine methylation using H4(1-20) and [14C]-acetyl CoA by scintillation counting | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.37E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of His6x-tagged PRMT1-mediated protein arginine methylation expressed in Escherichia coli BL21 (DE3) using H4(1-20) and [14C]-SAM by scint... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Salerno Curated by ChEMBL | Assay Description Binding affinity to human recombinant GST-PRMT1 expressed Escherichia coli BL21 by SPR assay | J Med Chem 55: 9875-90 (2012) Article DOI: 10.1021/jm301097p BindingDB Entry DOI: 10.7270/Q2445NM2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-University of Freiburg Curated by ChEMBL | Assay Description Inhibition of human recombinant PRMT1 by TRF assay | J Med Chem 50: 2319-25 (2007) Article DOI: 10.1021/jm061250e BindingDB Entry DOI: 10.7270/Q2862H8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RmtA (Emericella nidulans) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-University of Freiburg Curated by ChEMBL | Assay Description Inhibition of Aspergillus nidulans RmtA by TRF assay | J Med Chem 50: 2319-25 (2007) Article DOI: 10.1021/jm061250e BindingDB Entry DOI: 10.7270/Q2862H8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RmtA (Emericella nidulans) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of Aspergillus nidulans recombinant GST-RmtA expressed in BL21 cells | J Med Chem 50: 1241-53 (2007) Article DOI: 10.1021/jm061213n BindingDB Entry DOI: 10.7270/Q29887TV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of human recombinant GST-PRMT1 expressed in BL21 cells | J Med Chem 50: 1241-53 (2007) Article DOI: 10.1021/jm061213n BindingDB Entry DOI: 10.7270/Q29887TV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50206427 (7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.69E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells using Histone H4(1-20) substrate preincubated for 5 m... | J Med Chem 55: 7978-87 (2012) Article DOI: 10.1021/jm300521m BindingDB Entry DOI: 10.7270/Q2PN96R4 | |||||||||||
More data for this Ligand-Target Pair |