BDBM50207122 3-isobutyl-8-((7-methoxyisoquinolin-4-yl)methyl)-1-methyl-1H-purine-2,6(3H,7H)-dione::CHEMBL246266

SMILES: COc1ccc2c(Cc3nc4n(CC(C)C)c(=O)n(C)c(=O)c4[nH]3)cncc2c1

InChI Key: InChIKey=GFNFAFKKZDVOOR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50207122 (3-isobutyl-8-((7-methoxyisoquinolin-4-yl)methyl)-1...) Show SMILES COc1ccc2c(Cc3nc4n(CC(C)C)c(=O)n(C)c(=O)c4[nH]3)cncc2c1 Show InChI InChI=1S/C21H23N5O3/c1-12(2)11-26-19-18(20(27)25(3)21(26)28)23-17(24-19)8-14-10-22-9-13-7-15(29-4)5-6-16(13)14/h5-7,9-10,12H,8,11H2,1-4H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes of Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assay				Bioorg Med Chem Lett 17: 2376-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.019 BindingDB Entry DOI: 10.7270/Q2X63NSC
					More data for this Ligand-Target Pair