BDBM50207128 CHEMBL393913::N-(4-((8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl-2,6-dioxo-1,6-dihydro-2H-purin-3(7H)-yl)methyl)phenyl)acetamide

SMILES: COc1cc2cncc(Cc3nc4n(Cc5ccc(NC(C)=O)cc5)c(=O)n(C)c(=O)c4[nH]3)c2cc1OC

InChI Key: InChIKey=OSEDHANUBVQCTB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207128   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50207128 (CHEMBL393913 | N-(4-((8-((6,7-dimethoxyisoquinolin...) Show SMILES COc1cc2cncc(Cc3nc4n(Cc5ccc(NC(C)=O)cc5)c(=O)n(C)c(=O)c4[nH]3)c2cc1OC Show InChI InChI=1S/C27H26N6O5/c1-15(34)29-19-7-5-16(6-8-19)14-33-25-24(26(35)32(2)27(33)36)30-23(31-25)10-18-13-28-12-17-9-21(37-3)22(38-4)11-20(17)18/h5-9,11-13H,10,14H2,1-4H3,(H,29,34)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes of Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assay				Bioorg Med Chem Lett 17: 2376-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.019 BindingDB Entry DOI: 10.7270/Q2X63NSC
					More data for this Ligand-Target Pair