BDBM50207482 CHEMBL223237::N-{4-[3-amino-1-(2-morpholin-4-yl-ethyl)-1H-indazol-4-yl]-phenyl}-N'-(3-methylphenyl)urea

SMILES: Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(CCN4CCOCC4)nc(N)c23)c1

InChI Key: InChIKey=IOEOFPWILLIIMB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50207482   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207482 (CHEMBL223237 | N-{4-[3-amino-1-(2-morpholin-4-yl-e...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(CCN4CCOCC4)nc(N)c23)c1 Show InChI InChI=1S/C27H30N6O2/c1-19-4-2-5-22(18-19)30-27(34)29-21-10-8-20(9-11-21)23-6-3-7-24-25(23)26(28)31-33(24)13-12-32-14-16-35-17-15-32/h2-11,18H,12-17H2,1H3,(H2,28,31)(H2,29,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207482 (CHEMBL223237 | N-{4-[3-amino-1-(2-morpholin-4-yl-e...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3n(CCN4CCOCC4)nc(N)c23)c1 Show InChI InChI=1S/C27H30N6O2/c1-19-4-2-5-22(18-19)30-27(34)29-21-10-8-20(9-11-21)23-6-3-7-24-25(23)26(28)31-33(24)13-12-32-14-16-35-17-15-32/h2-11,18H,12-17H2,1H3,(H2,28,31)(H2,29,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair