Found 5 hits for monomerid = 50207486 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50207486
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR by HTRF assay |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50207486
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50207486
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Punjabi University
Curated by ChEMBL
| Assay Description Inhibition of c-Kit by HTRF method |
Eur J Med Chem 45: 393-404 (2010)
Article DOI: 10.1016/j.ejmech.2009.09.013 BindingDB Entry DOI: 10.7270/Q2RX9C6D |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50207486
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of c-Kit by HTRF assay |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50207486
(1-(4-(3-amino-7-(2-methoxyethoxy)-1H-indazol-4-yl)...)Show SMILES COCCOc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C24H25N5O3/c1-15-4-3-5-18(14-15)27-24(30)26-17-8-6-16(7-9-17)19-10-11-20(32-13-12-31-2)22-21(19)23(25)29-28-22/h3-11,14H,12-13H2,1-2H3,(H3,25,28,29)(H2,26,27,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of FLT3 by HTRF assay |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this Ligand-Target Pair | |