BDBM50207494 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorophenyl)urea::CHEMBL220049::N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(4-fluorophenyl)-urea

SMILES: Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12

InChI Key: InChIKey=RPCMGDNNIFRGGQ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207494   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207494 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorop...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12 Show InChI InChI=1S/C20H16FN5O/c21-13-6-10-15(11-7-13)24-20(27)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207494 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorop...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12 Show InChI InChI=1S/C20H16FN5O/c21-13-6-10-15(11-7-13)24-20(27)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Punjabi University Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF method				Eur J Med Chem 45: 393-404 (2010) Article DOI: 10.1016/j.ejmech.2009.09.013 BindingDB Entry DOI: 10.7270/Q2RX9C6D
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207494 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorop...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12 Show InChI InChI=1S/C20H16FN5O/c21-13-6-10-15(11-7-13)24-20(27)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207494 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluorop...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12 Show InChI InChI=1S/C20H16FN5O/c21-13-6-10-15(11-7-13)24-20(27)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair