BDBM50207495 CHEMBL222918::N-[4-(3-dimethylamino-1-methyl-1H-indazol-4-yl)phenyl]-N'-(3-methylpheny)urea

SMILES: CN(C)c1nn(C)c2cccc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c12

InChI Key: InChIKey=ONOOIKUMYMBVRN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207495   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207495 (CHEMBL222918 | N-[4-(3-dimethylamino-1-methyl-1H-i...) Show SMILES CN(C)c1nn(C)c2cccc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c12 Show InChI InChI=1S/C24H25N5O/c1-16-7-5-8-19(15-16)26-24(30)25-18-13-11-17(12-14-18)20-9-6-10-21-22(20)23(28(2)3)27-29(21)4/h5-15H,1-4H3,(H2,25,26,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair