BDBM50207498 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-3-yl)urea::CHEMBL376307::N-[4-(3-amino-1H-indazol-4-yl)-phenyl]-N'-thiophen-3-ylurea

SMILES: Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12

InChI Key: InChIKey=OPVYNMNWPXOEJX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207498 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12 Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207498 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12 Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Punjabi University Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF method				Eur J Med Chem 45: 393-404 (2010) Article DOI: 10.1016/j.ejmech.2009.09.013 BindingDB Entry DOI: 10.7270/Q2RX9C6D
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207498 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12 Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207498 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12 Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair