BDBM50207514 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea::CHEMBL219722::N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-phenylurea

SMILES: Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12

InChI Key: InChIKey=UXMNYFJHEBEDJS-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207514 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 Show InChI InChI=1S/C20H17N5O/c21-19-18-16(7-4-8-17(18)24-25-19)13-9-11-15(12-10-13)23-20(26)22-14-5-2-1-3-6-14/h1-12H,(H3,21,24,25)(H2,22,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207514 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 Show InChI InChI=1S/C20H17N5O/c21-19-18-16(7-4-8-17(18)24-25-19)13-9-11-15(12-10-13)23-20(26)22-14-5-2-1-3-6-14/h1-12H,(H3,21,24,25)(H2,22,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207514 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 Show InChI InChI=1S/C20H17N5O/c21-19-18-16(7-4-8-17(18)24-25-19)13-9-11-15(12-10-13)23-20(26)22-14-5-2-1-3-6-14/h1-12H,(H3,21,24,25)(H2,22,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207514 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-phenylurea...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 Show InChI InChI=1S/C20H17N5O/c21-19-18-16(7-4-8-17(18)24-25-19)13-9-11-15(12-10-13)23-20(26)22-14-5-2-1-3-6-14/h1-12H,(H3,21,24,25)(H2,22,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair