BindingDB PrimarySearch

BDBM50207795 CHEMBL246952::adamantan-1-yl-(3,4-dihydro-2H-quinolin-1-yl)-methanone

SMILES: O=C(N1CCCc2ccccc12)C12CC3CC(CC(C3)C1)C2

InChI Key: InChIKey=KDDFVDYZIBZTGJ-UHFFFAOYSA-N

Data: 2 KI 2 IC50 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50207795
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Binding affinity to human CB2 receptor				Bioorg Med Chem Lett 23: 1177-81 (2013) Article DOI: 10.1016/j.bmcl.2013.01.044 BindingDB Entry DOI: 10.7270/Q2M32X3H
F. Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (MOUSE)	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Binding affinity to mouse CB2 receptor				Bioorg Med Chem Lett 23: 1177-81 (2013) Article DOI: 10.1016/j.bmcl.2013.01.044 BindingDB Entry DOI: 10.7270/Q2M32X3H
F. Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (MOUSE)	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	126	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at mouse CB2 receptor by cAMP read-out assay				Bioorg Med Chem Lett 23: 1177-81 (2013) Article DOI: 10.1016/j.bmcl.2013.01.044 BindingDB Entry DOI: 10.7270/Q2M32X3H
F. Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at human CB1 receptor by cAMP read-out assay				Bioorg Med Chem Lett 23: 1177-81 (2013) Article DOI: 10.1016/j.bmcl.2013.01.044 BindingDB Entry DOI: 10.7270/Q2M32X3H
F. Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at human CB2 receptor by cAMP read-out assay				Bioorg Med Chem Lett 23: 1177-81 (2013) Article DOI: 10.1016/j.bmcl.2013.01.044 BindingDB Entry DOI: 10.7270/Q2M32X3H
F. Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Mus musculus (Mouse))	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at mouse CB1 receptor by cAMP read-out assay				Bioorg Med Chem Lett 23: 1177-81 (2013) Article DOI: 10.1016/j.bmcl.2013.01.044 BindingDB Entry DOI: 10.7270/Q2M32X3H
F. Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	481	n/a	n/a	n/a	n/a	n/a	n/a
University of Edinburgh Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 4 hrs by scintillation proximity assay				Bioorg Med Chem Lett 17: 2838-43 (2007) Article DOI: 10.1016/j.bmcl.2007.02.057 BindingDB Entry DOI: 10.7270/Q2CJ8D5S
University of Edinburgh Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Edinburgh Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells after 2 hrs by scintillation proximity assay				Bioorg Med Chem Lett 17: 2838-43 (2007) Article DOI: 10.1016/j.bmcl.2007.02.057 BindingDB Entry DOI: 10.7270/Q2CJ8D5S
University of Edinburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50207795 (CHEMBL246952 \| adamantan-1-yl-(3,4-dihydro-2H-quin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at human CB2 receptor by beta-arrestin recruitment assay				Bioorg Med Chem Lett 23: 1177-81 (2013) Article DOI: 10.1016/j.bmcl.2013.01.044 BindingDB Entry DOI: 10.7270/Q2M32X3H
F. Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair