BDBM50208135 (+)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-dihydro-furan-2-carboxylic acid::(-)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-dihydro-furan-2-carboxylic acid::5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-dihydro-furan-2-carboxylic acid::CHEMBL424938
SMILES: Cc1cc(cs1)C1(C)OC(=CC1=O)C(O)=O
InChI Key: InChIKey=NNWGOUJBCKZULC-UHFFFAOYSA-N
Data: 3 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human)) | BDBM50208135 ((+)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation | J Med Chem 50: 1445-8 (2007) Article DOI: 10.1021/jm070022x BindingDB Entry DOI: 10.7270/Q2BK1C1Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human)) | BDBM50208135 ((+)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation | J Med Chem 50: 1445-8 (2007) Article DOI: 10.1021/jm070022x BindingDB Entry DOI: 10.7270/Q2BK1C1Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HM74 nicotinic acid GPCR (Homo sapiens (Human)) | BDBM50208135 ((+)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation | J Med Chem 50: 1445-8 (2007) Article DOI: 10.1021/jm070022x BindingDB Entry DOI: 10.7270/Q2BK1C1Z | |||||||||||
More data for this Ligand-Target Pair |