BDBM50208202 CHEMBL3885280

SMILES: C(CN1CCCCC1)Nc1nc2ccccc2c2nc3ccccc3nc12

InChI Key: InChIKey=CEIAXKDGEIABIM-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208202   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Topoisomerase II alpha (HuTopoIIα) (Homo sapiens (Human))	BDBM50208202 (CHEMBL3885280) Show SMILES C(CN1CCCCC1)Nc1nc2ccccc2c2nc3ccccc3nc12 Show InChI InChI=1S/C22H23N5/c1-6-13-27(14-7-1)15-12-23-22-21-20(16-8-2-3-9-17(16)26-22)24-18-10-4-5-11-19(18)25-21/h2-5,8-11H,1,6-7,12-15H2,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari"Aldo Moro" Curated by ChEMBL					Assay Description Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresis				Eur J Med Chem 123: 704-717 (2016) Article DOI: 10.1016/j.ejmech.2016.07.063 BindingDB Entry DOI: 10.7270/Q2TQ63HJ
					More data for this Ligand-Target Pair