BDBM50208577 (R)-3-((2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)ethynyl)quinuclidin-3-ol::(R)-3-(2-(2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)ethynyl)quinuclidin-3-ol::CHEMBL258503::ER-119884
SMILES: COCCCOc1ccc(C#C[C@@]2(O)CN3CCC2CC3)c(Cc2ccccc2)n1
InChI Key: InChIKey=HVIKCINYHLGLMN-RUZDIDTESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Squalene synthetase (Homo sapiens (Human)) | BDBM50208577 ((R)-3-((2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto de Parasitolog£a y Biomedicina"L£pez-Neyra Curated by ChEMBL | Assay Description Inhibition of human recombinant squalene synthase | Antimicrob Agents Chemother 51: 2123-9 (2007) Article DOI: 10.1128/AAC.01454-06 BindingDB Entry DOI: 10.7270/Q2BC40DD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Farnesyltransferase, putative (Leishmania major) | BDBM50208577 ((R)-3-((2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair |