BDBM50208750 1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL395981

SMILES: CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1

InChI Key: InChIKey=BTMYCYUSKNWPJE-MBIULKOWSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50208750   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50208750 (1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)...) Show SMILES CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 Show InChI InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA2 after 15 mins by CO2 hydration stopped flow assay				Bioorg Med Chem Lett 17: 2685-91 (2007) Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D
					More data for this Ligand-Target Pair
Carbonic Anhydrase XIV (Homo sapiens (Human))	BDBM50208750 (1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)...) Show SMILES CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 Show InChI InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA14 after 15 mins by CO2 hydration stopped flow assay				Bioorg Med Chem Lett 17: 2685-91 (2007) Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D
					More data for this Ligand-Target Pair
Carbonic anhydrase 7 (Homo sapiens (Human))	BDBM50208750 (1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)...) Show SMILES CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 Show InChI InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA7 after 15 mins by CO2 hydration stopped flow assay				Bioorg Med Chem Lett 17: 2685-91 (2007) Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50208750 (1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)...) Show SMILES CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 Show InChI InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA9 after 15 mins by CO2 hydration stopped flow assay				Bioorg Med Chem Lett 17: 2685-91 (2007) Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D
					More data for this Ligand-Target Pair
Carbonic Anhydrase VA (Homo sapiens (Human))	BDBM50208750 (1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)...) Show SMILES CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 Show InChI InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA5A after 15 mins by CO2 hydration stopped flow assay				Bioorg Med Chem Lett 17: 2685-91 (2007) Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50208750 (1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)...) Show SMILES CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 Show InChI InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA1 after 15 mins by CO2 hydration stopped flow assay				Bioorg Med Chem Lett 17: 2685-91 (2007) Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D
					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50208750 (1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)...) Show SMILES CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 Show InChI InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	8.93E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA4 after 15 mins by CO2 hydration stopped flow assay				Bioorg Med Chem Lett 17: 2685-91 (2007) Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D
					More data for this Ligand-Target Pair