Found 21 hits for monomerid = 50209245 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Nitric oxide synthase, brain
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | 2.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Groton
Curated by ChEMBL
| Assay Description Inhibitory activity against human neuronal nitric oxide synthase (nNOS) |
Bioorg Med Chem Lett 9: 2569-72 (1999)
BindingDB Entry DOI: 10.7270/Q2BC3XRP |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Rattus norvegicus) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hradec Kralove
Curated by ChEMBL
| Assay Description Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 mins |
Eur J Med Chem 168: 491-514 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.021 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric-oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | 2.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Groton
Curated by ChEMBL
| Assay Description Inhibitory activity against rat neuronal nitric oxide synthase (nNOS) |
Bioorg Med Chem Lett 9: 2569-72 (1999)
BindingDB Entry DOI: 10.7270/Q2BC3XRP |
More data for this Ligand-Target Pair | |
Nitric-oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Caen
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against rat cerebellar neuronal nitric oxide synthase |
Bioorg Med Chem Lett 11: 1153-6 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6QS3 |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description In vitro inhibition of human neuronal nitric oxide synthase |
J Med Chem 47: 1575-86 (2004)
Article DOI: 10.1021/jm030519g BindingDB Entry DOI: 10.7270/Q2J102MT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description In vitro inhibition of human endothelial nitric oxide synthase |
J Med Chem 47: 1575-86 (2004)
Article DOI: 10.1021/jm030519g BindingDB Entry DOI: 10.7270/Q2J102MT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric-oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
UPRES-EA 3915
Curated by ChEMBL
| Assay Description Inhibition of rat neuronal NOS |
Bioorg Med Chem Lett 17: 3177-80 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.024 BindingDB Entry DOI: 10.7270/Q2Z60NR3 |
More data for this Ligand-Target Pair | |
Nitric-oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Versailles
Curated by ChEMBL
| Assay Description Inhibition of rat brain recombinant nNOS |
Bioorg Med Chem 16: 5962-73 (2008)
Article DOI: 10.1016/j.bmc.2008.04.056 BindingDB Entry DOI: 10.7270/Q2GB23VM |
More data for this Ligand-Target Pair | |
Nitric Oxide Synthase, inducible
(Mus musculus (mouse)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Versailles
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant iNOS |
Bioorg Med Chem 16: 5962-73 (2008)
Article DOI: 10.1016/j.bmc.2008.04.056 BindingDB Entry DOI: 10.7270/Q2GB23VM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric Oxide Synthase, endothelial
(Bos taurus (bovine)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Versailles
Curated by ChEMBL
| Assay Description Inhibition of bovine recombinant eNOS |
Bioorg Med Chem 16: 5962-73 (2008)
Article DOI: 10.1016/j.bmc.2008.04.056 BindingDB Entry DOI: 10.7270/Q2GB23VM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric Oxide Synthase, inducible
(Mus musculus (mouse)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested to inhibit the conversion of [3H]-L-arginine to [3H]-L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells |
Bioorg Med Chem Lett 5: 1573-1576 (1995)
Article DOI: 10.1016/0960-894X(95)00273-V BindingDB Entry DOI: 10.7270/Q25T3KD0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric oxide synthase, inducible
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested to inhibit the conversion of [3H]-L-arginine to [3H]-L-citrulline catalyzed by inducible NOS from human DLD-1 cells. |
Bioorg Med Chem Lett 5: 1573-1576 (1995)
Article DOI: 10.1016/0960-894X(95)00273-V BindingDB Entry DOI: 10.7270/Q25T3KD0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric-oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested to inhibit the conversion of [3H]-L-arginine to [3H]-L-citrulline catalyzed by neuronal NOS from rat cerebellum. |
Bioorg Med Chem Lett 5: 1573-1576 (1995)
Article DOI: 10.1016/0960-894X(95)00273-V BindingDB Entry DOI: 10.7270/Q25T3KD0 |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested to inhibit the conversion of [3H]-L-arginine to [3H]-L-citrulline catalyzed by endothelial NOS from human umbilical vein endothelial cells. |
Bioorg Med Chem Lett 5: 1573-1576 (1995)
Article DOI: 10.1016/0960-894X(95)00273-V BindingDB Entry DOI: 10.7270/Q25T3KD0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric oxide synthase, brain
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
UNED
Curated by ChEMBL
| Assay Description Inhibition of NOS1 |
Bioorg Med Chem 17: 6180-7 (2009)
Article DOI: 10.1016/j.bmc.2009.07.067 BindingDB Entry DOI: 10.7270/Q2ZG6SBD |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNED
Curated by ChEMBL
| Assay Description Inhibition of NOS2 |
Bioorg Med Chem 17: 6180-7 (2009)
Article DOI: 10.1016/j.bmc.2009.07.067 BindingDB Entry DOI: 10.7270/Q2ZG6SBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric-oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University
Curated by ChEMBL
| Assay Description Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visibl... |
Bioorg Med Chem 19: 3935-44 (2011)
Article DOI: 10.1016/j.bmc.2011.05.034 BindingDB Entry DOI: 10.7270/Q2H132CH |
More data for this Ligand-Target Pair | |
Nitric Oxide Synthase, endothelial
(Bos taurus (bovine)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Christian-Albrechts-University of Kiel
Curated by ChEMBL
| Assay Description Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioacti... |
Eur J Med Chem 44: 2877-87 (2009)
Article DOI: 10.1016/j.ejmech.2008.12.007 BindingDB Entry DOI: 10.7270/Q2KD1ZV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric Oxide Synthase, inducible
(Mus musculus (mouse)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Christian-Albrechts-University of Kiel
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactiv... |
Eur J Med Chem 44: 2877-87 (2009)
Article DOI: 10.1016/j.ejmech.2008.12.007 BindingDB Entry DOI: 10.7270/Q2KD1ZV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric-oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Christian-Albrechts-University of Kiel
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant nNOS expressed in Saccharomyces cerevisiae assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radi... |
Eur J Med Chem 44: 2877-87 (2009)
Article DOI: 10.1016/j.ejmech.2008.12.007 BindingDB Entry DOI: 10.7270/Q2KD1ZV6 |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
| PDB PubMed
| n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Groton
Curated by ChEMBL
| Assay Description Inhibitory activity against human endothelial nitric oxide synthase (eNOS) |
Bioorg Med Chem Lett 9: 2569-72 (1999)
BindingDB Entry DOI: 10.7270/Q2BC3XRP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |