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BDBM50209516 4-[3-cyano-2-(2'-ethoxy-2-methyl-biphenyl-4-yl)-6-fluoro-quinolin-4-ylamino]-butyric acid::CHEMBL246142

SMILES: CCOc1ccccc1-c1ccc(cc1C)-c1nc2ccc(F)cc2c(NCCCC(O)=O)c1C#N

InChI Key: InChIKey=ZBJDOHIXRMELIW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209516   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209516
PNG
(4-[3-cyano-2-(2'-ethoxy-2-methyl-biphenyl-4-yl)-6-...)
Show SMILES CCOc1ccccc1-c1ccc(cc1C)-c1nc2ccc(F)cc2c(NCCCC(O)=O)c1C#N
Show InChI InChI=1S/C29H26FN3O3/c1-3-36-26-8-5-4-7-22(26)21-12-10-19(15-18(21)2)28-24(17-31)29(32-14-6-9-27(34)35)23-16-20(30)11-13-25(23)33-28/h4-5,7-8,10-13,15-16H,3,6,9,14H2,1-2H3,(H,32,33)(H,34,35)
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MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair