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BDBM50209521 3-[2-(2'-trifluoromethyl-biphenyl-4-yl)-quinolin-4-ylamino]-propionic acid::CHEMBL439043

SMILES: OC(=O)CCNc1cc(nc2ccccc12)-c1ccc(cc1)-c1ccccc1C(F)(F)F

InChI Key: InChIKey=YSPVSIDYPNVZFB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209521   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209521
PNG
(3-[2-(2'-trifluoromethyl-biphenyl-4-yl)-quinolin-4...)
Show SMILES OC(=O)CCNc1cc(nc2ccccc12)-c1ccc(cc1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H19F3N2O2/c26-25(27,28)20-7-3-1-5-18(20)16-9-11-17(12-10-16)22-15-23(29-14-13-24(31)32)19-6-2-4-8-21(19)30-22/h1-12,15H,13-14H2,(H,29,30)(H,31,32)
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair