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BDBM50209523 CHEMBL247973::[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-quinolin-4-ylamino]-acetic acid

SMILES: CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(NCC(O)=O)c1C#N

InChI Key: InChIKey=BIQBTSGPKAVRDG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209523   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209523
PNG
(CHEMBL247973 | [3-cyano-2-(2'-ethoxy-biphenyl-4-yl...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(NCC(O)=O)c1C#N
Show InChI InChI=1S/C26H20FN3O3/c1-2-33-23-6-4-3-5-19(23)16-7-9-17(10-8-16)25-21(14-28)26(29-15-24(31)32)20-13-18(27)11-12-22(20)30-25/h3-13H,2,15H2,1H3,(H,29,30)(H,31,32)
PDB
MMDB

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PC cid
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n/an/a 7n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair