BDBM50209532 2-{[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-quinolin-4-yl]-methyl-amino}-propionic acid::CHEMBL392183

SMILES: CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(N(C)C(C)C(O)=O)c1C#N

InChI Key: InChIKey=COHAJIOMCQCWQI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209532   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50209532 (2-{[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-q...) Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(N(C)C(C)C(O)=O)c1C#N |w:27.30| Show InChI InChI=1S/C28H24FN3O3/c1-4-35-25-8-6-5-7-21(25)18-9-11-19(12-10-18)26-23(16-30)27(32(3)17(2)28(33)34)22-15-20(29)13-14-24(22)31-26/h5-15,17H,4H2,1-3H3,(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Pharmaceuticals Corporation Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay				Bioorg Med Chem Lett 17: 2869-73 (2007) Article DOI: 10.1016/j.bmcl.2007.02.061 BindingDB Entry DOI: 10.7270/Q2NS0TK0
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