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BDBM50209533 (R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-7-methyl-quinolin-4-ylamino]-propionic acid::CHEMBL397774

SMILES: CCOc1ccccc1-c1ccc(cc1)-c1nc2cc(C)ccc2c(N[C@H](C)C(O)=O)c1C#N

InChI Key: InChIKey=XZUXLKPYCZGTPW-GOSISDBHSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209533   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209533
PNG
((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-7-methy...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2cc(C)ccc2c(N[C@H](C)C(O)=O)c1C#N
Show InChI InChI=1S/C28H25N3O3/c1-4-34-25-8-6-5-7-21(25)19-10-12-20(13-11-19)26-23(16-29)27(30-18(3)28(32)33)22-14-9-17(2)15-24(22)31-26/h5-15,18H,4H2,1-3H3,(H,30,31)(H,32,33)/t18-/m1/s1
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair