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BDBM50209537 CHEMBL391364::{[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-quinolin-4-yl]-phenyl-amino}-acetic acid

SMILES: CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(N(CC(O)=O)c2ccccc2)c1C#N

InChI Key: InChIKey=VOLNDMYSCVVZFU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209537   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209537
PNG
(CHEMBL391364 | {[3-cyano-2-(2'-ethoxy-biphenyl-4-y...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(N(CC(O)=O)c2ccccc2)c1C#N
Show InChI InChI=1S/C32H24FN3O3/c1-2-39-29-11-7-6-10-25(29)21-12-14-22(15-13-21)31-27(19-34)32(26-18-23(33)16-17-28(26)35-31)36(20-30(37)38)24-8-4-3-5-9-24/h3-18H,2,20H2,1H3,(H,37,38)
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MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair