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BDBM50209543 (R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-quinolin-4-ylamino]-propionic acid::CHEMBL248058

SMILES: CCOc1ccccc1-c1ccc(cc1)-c1nc2ccccc2c(N[C@H](C)C(O)=O)c1C#N

InChI Key: InChIKey=UXDIQNWZOHMMMV-QGZVFWFLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209543   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209543
PNG
((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-quinoli...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccccc2c(N[C@H](C)C(O)=O)c1C#N
Show InChI InChI=1S/C27H23N3O3/c1-3-33-24-11-7-5-8-20(24)18-12-14-19(15-13-18)25-22(16-28)26(29-17(2)27(31)32)21-9-4-6-10-23(21)30-25/h4-15,17H,3H2,1-2H3,(H,29,30)(H,31,32)/t17-/m1/s1
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PC cid
PC sid
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Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair