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BDBM50209546 (R)-2-[3-cyano-2-(2'-ethoxy-3-fluoro-biphenyl-4-yl)-6-fluoro-quinolin-4-ylamino]-propionic acid::CHEMBL246344

SMILES: CCOc1ccccc1-c1ccc(c(F)c1)-c1nc2ccc(F)cc2c(N[C@H](C)C(O)=O)c1C#N

InChI Key: InChIKey=VFCIRWBTDSPGFT-OAHLLOKOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209546   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209546
PNG
((R)-2-[3-cyano-2-(2'-ethoxy-3-fluoro-biphenyl-4-yl...)
Show SMILES CCOc1ccccc1-c1ccc(c(F)c1)-c1nc2ccc(F)cc2c(N[C@H](C)C(O)=O)c1C#N
Show InChI InChI=1S/C27H21F2N3O3/c1-3-35-24-7-5-4-6-18(24)16-8-10-19(22(29)12-16)25-21(14-30)26(31-15(2)27(33)34)20-13-17(28)9-11-23(20)32-25/h4-13,15H,3H2,1-2H3,(H,31,32)(H,33,34)/t15-/m1/s1
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PC cid
PC sid
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Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair