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SMILES: CCOc1ccccc1-c1ccc(cc1C)-c1nc2ccc(F)cc2c(N[C@H](C)C(O)=O)c1C#N

InChI Key: InChIKey=BDSNLFMNXLDPFX-QGZVFWFLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50209549   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50209549
PNG
((R)-2-[3-cyano-2-(2'-ethoxy-2-methyl-biphenyl-4-yl...)
Show SMILES CCOc1ccccc1-c1ccc(cc1C)-c1nc2ccc(F)cc2c(N[C@H](C)C(O)=O)c1C#N
Show InChI InChI=1S/C28H24FN3O3/c1-4-35-25-8-6-5-7-21(25)20-11-9-18(13-16(20)2)26-23(15-30)27(31-17(3)28(33)34)22-14-19(29)10-12-24(22)32-26/h5-14,17H,4H2,1-3H3,(H,31,32)(H,33,34)/t17-/m1/s1
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Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay

Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair