BDBM50210461 (stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E)-1-ethenyl]phenyl-iminomethanamine::4,4'-(ethene-1,2-diyl)dibenzimidamide::4-((E)-2-{4-[(Z)-amino(imino)methyl]phenyl}vinyl)benzenecarboximidamide::4-((E)-2-{4-[(Z)-amino(imino)methyl]phenyl}vinyl)benzenecarboximidamide(stilbamidine isethionate)::CHEMBL142304::NSC-35605::stilbamidine
SMILES: NC(=N)c1ccc(\C=C\c2ccc(cc2)C(N)=N)cc1
InChI Key: InChIKey=MMURVNDSFNJHAM-OWOJBTEDSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | 2.56E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of His6x-tagged PRMT1-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using H4(1-11) and [14C]-SAM by scintillation... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Binding affinity to His6x-tagged PRMT1 expressed in Escherichia coli BL21 (DE3) using fluorescein-labeled H4(1-11) peptide by spectrofluorometer anal... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-arginine methyltransferase CARM1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Georgia Curated by ChEMBL | Assay Description Inhibition of GST-tagged CARM1 (unknown origin) using [3H]SAM and histone H3.1 as substrate at 20 uM after 1 hr by P81 filter binding assay | J Med Chem 57: 2611-22 (2014) Article DOI: 10.1021/jm401884z BindingDB Entry DOI: 10.7270/Q2ZW1NFB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein arginine N-methyltransferase 6 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.73E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Georgia Curated by ChEMBL | Assay Description Inhibition of His6x-tagged PRMT6 (unknown origin) using [3H]SAM and histone H3.1 as substrate at 20 uM after 1 hr by P81 filter binding assay | J Med Chem 57: 2611-22 (2014) Article DOI: 10.1021/jm401884z BindingDB Entry DOI: 10.7270/Q2ZW1NFB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 5.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of human GST-tagged PRMT1-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using H4(1-20) and [14C]-AdoMet by scinti... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of His6x-tagged PRMT1-mediated protein arginine methylation expressed in Escherichia coli BL21 (DE3) using H4(1-20) and [14C]-SAM by scint... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 5.69E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-University of Freiburg Curated by ChEMBL | Assay Description Inhibition of human recombinant PRMT1 by TRF assay | J Med Chem 50: 2319-25 (2007) Article DOI: 10.1021/jm061250e BindingDB Entry DOI: 10.7270/Q2862H8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RmtA (Emericella nidulans) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 2.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-University of Freiburg Curated by ChEMBL | Assay Description Inhibition of Aspergillus nidulans RmtA by TRF assay | J Med Chem 50: 2319-25 (2007) Article DOI: 10.1021/jm061250e BindingDB Entry DOI: 10.7270/Q2862H8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 4.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Georgia Curated by ChEMBL | Assay Description Inhibition of HA-tagged recombinant PRMT5 (unknown origin) expressed in HEK293T cells using [3H]SAM and histone H4 (1 to 20) as substrate after 8 min... | J Med Chem 57: 2611-22 (2014) Article DOI: 10.1021/jm401884z BindingDB Entry DOI: 10.7270/Q2ZW1NFB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Georgia Curated by ChEMBL | Assay Description Inhibition of His6x-tagged recombinant PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]SAM and histone H4 (1 to 20) as subst... | J Med Chem 57: 2611-22 (2014) Article DOI: 10.1021/jm401884z BindingDB Entry DOI: 10.7270/Q2ZW1NFB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50210461 ((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...) | PDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.15E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of His6x-tagged PRMT1-mediated protein arginine methylation expressed in Escherichia coli BL21 (DE3) using GAR R4 peptide and [14C]-AdoMet... | J Med Chem 53: 6028-39 (2010) Article DOI: 10.1021/jm100416n BindingDB Entry DOI: 10.7270/Q2251JDB | |||||||||||
More data for this Ligand-Target Pair |