BindingDB PrimarySearch

BDBM50211362 5-methyl-1H-pyrazole-3-carboxylic acid::5-methyl-3-carboxyl-pyrazole::5-methylpyrazole-3-carboxylic acid::CHEMBL391574

SMILES: Cc1cc(n[nH]1)C(O)=O

InChI Key: InChIKey=WSMQKESQZFQMFW-UHFFFAOYSA-N

Data: 7 IC50 2 Kd 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50211362
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay				Bioorg Med Chem Lett 17: 5620-3 (2007) Checked by Author Article DOI: 10.1016/j.bmcl.2007.07.101 BindingDB Entry DOI: 10.7270/Q2TT4QN2
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University Curated by ChEMBL					Assay Description Inhibition of human D-amino acid oxidase				ACS Med Chem Lett 5: 1251-3 (2014) Article DOI: 10.1021/ml500335z BindingDB Entry DOI: 10.7270/Q2GB25M9
Johns Hopkins University Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay				Bioorg Med Chem Lett 17: 5620-3 (2007) Checked by Author Article DOI: 10.1016/j.bmcl.2007.07.101 BindingDB Entry DOI: 10.7270/Q2TT4QN2
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	460	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test				Bioorg Med Chem Lett 17: 4914-9 (2007) Article DOI: 10.1016/j.bmcl.2007.06.028 BindingDB Entry DOI: 10.7270/Q2NP244M
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	473	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc...				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
Abbott Healthcare Products B.V. Curated by ChEMBL					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Inhibition of human DAAO				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
Abbott Healthcare Products B.V. Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
"Sapienza" Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin...				ACS Med Chem Lett 11: 798-805 (2020)
"Sapienza" Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
Abbott Healthcare Products B.V. Curated by ChEMBL					More data for this Ligand-Target Pair
D-aspartate oxidase (Bos taurus)	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assay				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
Abbott Healthcare Products B.V. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp technique				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
Abbott Healthcare Products B.V. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.34E+5	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate...				J Biol Chem 282: 18028-36 (2007) Article DOI: 10.1074/jbc.M701866200 BindingDB Entry DOI: 10.7270/Q2BV7HJC
Arena Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
Arena Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA				J Biol Chem 282: 18028-36 (2007) Article DOI: 10.1074/jbc.M701866200 BindingDB Entry DOI: 10.7270/Q2BV7HJC
Arena Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM50211362 (5-methyl-1H-pyrazole-3-carboxylic acid \| 5-methyl-...) Show SMILES Cc1cc(n[nH]1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	617	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
Abbott Healthcare Products B.V. Curated by ChEMBL					More data for this Ligand-Target Pair