BDBM50212273 3-(3-(1,4,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethoxy)phenyl)acrylic acid::CHEMBL247836
SMILES: CN1C(=O)CC(C)(C)c2cc(C)c(cc12)-c1cc(\C=C\C(O)=O)ccc1OC(F)(F)F
InChI Key: InChIKey=OFANDPMVUOFJJR-SOFGYWHQSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50212273 (3-(3-(1,4,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 24.3 | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Activity at RXRalpha by GAL4DNA cotransfection assay | Bioorg Med Chem Lett 17: 3497-503 (2007) Article DOI: 10.1016/j.bmcl.2007.01.047 BindingDB Entry DOI: 10.7270/Q2FQ9W93 | |||||||||||
More data for this Ligand-Target Pair |