BDBM50212408 2-(3-(1,4,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(2,2,2-trifluoroethoxy)phenyl)cyclopropanecarboxylic acid::CHEMBL247400

SMILES: CN1C(=O)CC(C)(C)c2cc(C)c(cc12)-c1cc(ccc1OCC(F)(F)F)C1CC1C(O)=O

InChI Key: InChIKey=ICPNIFOBOKKLKY-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212408   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50212408 (2-(3-(1,4,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydro...) Show SMILES CN1C(=O)CC(C)(C)c2cc(C)c(cc12)-c1cc(ccc1OCC(F)(F)F)C1CC1C(O)=O |w:27.29,29.33| Show InChI InChI=1S/C25H26F3NO4/c1-13-7-19-20(29(4)22(30)11-24(19,2)3)10-15(13)17-8-14(16-9-18(16)23(31)32)5-6-21(17)33-12-25(26,27)28/h5-8,10,16,18H,9,11-12H2,1-4H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	144	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Activity at RXRalpha by GAL4DNA cotransfection assay				Bioorg Med Chem Lett 17: 3491-6 (2007) Article DOI: 10.1016/j.bmcl.2007.01.049 BindingDB Entry DOI: 10.7270/Q2T153B1
					More data for this Ligand-Target Pair