BDBM50212426 3-(3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethoxy)phenyl)-2-methylacrylic acid::CHEMBL248016
SMILES: CCN1C(=O)CC(C)(C)c2cc(C)c(cc12)-c1cc(\C=C(/C)C(O)=O)ccc1OC(F)(F)F
InChI Key: InChIKey=ZNWMKEZRKRAMJI-OQLLNIDSSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50212426 (3-(3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrah...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 27.9 | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Activity at RXRalpha by GAL4DNA cotransfection assay | Bioorg Med Chem Lett 17: 3491-6 (2007) Article DOI: 10.1016/j.bmcl.2007.01.049 BindingDB Entry DOI: 10.7270/Q2T153B1 | |||||||||||
More data for this Ligand-Target Pair |