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SMILES: OCCNCC(=O)Nc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)c1

InChI Key: InChIKey=FKHFKEPLNJZRKD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212491   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50212491
PNG
(CHEMBL234656 | N-[3-(4'-hydroxy-biphenyl-4-yl)-1,4...)
Show SMILES OCCNCC(=O)Nc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)c1
Show InChI InChI=1S/C26H24N4O3/c31-12-11-27-15-24(33)28-20-7-10-22-19(13-20)14-23-25(29-30-26(22)23)18-3-1-16(2-4-18)17-5-8-21(32)9-6-17/h1-10,13,27,31-32H,11-12,14-15H2,(H,28,33)(H,29,30)
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n/an/a 0.740n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 mins

Bioorg Med Chem Lett 17: 3618-23 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.055
BindingDB Entry DOI: 10.7270/Q2DR2V6Q
More data for this
Ligand-Target Pair