BDBM50212502 4'-{6-[(2-hydroxy-ethylamino)-methyl]-7-methoxy-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-biphenyl-4-ol::CHEMBL232809

SMILES: COc1cc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)cc1CNCCO

InChI Key: InChIKey=TXYXKQLGTOSEMN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212502   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50212502 (4'-{6-[(2-hydroxy-ethylamino)-methyl]-7-methoxy-1,...) Show SMILES COc1cc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)cc1CNCCO Show InChI InChI=1S/C26H25N3O3/c1-32-24-14-22-19(12-20(24)15-27-10-11-30)13-23-25(28-29-26(22)23)18-4-2-16(3-5-18)17-6-8-21(31)9-7-17/h2-9,12,14,27,30-31H,10-11,13,15H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 mins				Bioorg Med Chem Lett 17: 3618-23 (2007) Article DOI: 10.1016/j.bmcl.2007.04.055 BindingDB Entry DOI: 10.7270/Q2DR2V6Q
					More data for this Ligand-Target Pair