BDBM50212687 2-(3-chloro-benzyl)-5-trifluoromethoxy-2,3-dihydro-isoindol-1-ylideneamine::CHEMBL247718

SMILES: FC(F)(F)Oc1ccc2C(=N)N(Cc3cccc(Cl)c3)Cc2c1

InChI Key: InChIKey=PVDYHVJORZHHLG-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50212687   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50212687 (2-(3-chloro-benzyl)-5-trifluoromethoxy-2,3-dihydro...) Show SMILES FC(F)(F)Oc1ccc2C(=N)N(Cc3cccc(Cl)c3)Cc2c1 Show InChI InChI=1S/C16H12ClF3N2O/c17-12-3-1-2-10(6-12)8-22-9-11-7-13(23-16(18,19)20)4-5-14(11)15(22)21/h1-7,21H,8-9H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity to NMDA NR2B receptor				Bioorg Med Chem Lett 17: 3997-4000 (2007) Article DOI: 10.1016/j.bmcl.2007.04.084 BindingDB Entry DOI: 10.7270/Q21J99GV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50212687 (2-(3-chloro-benzyl)-5-trifluoromethoxy-2,3-dihydro...) Show SMILES FC(F)(F)Oc1ccc2C(=N)N(Cc3cccc(Cl)c3)Cc2c1 Show InChI InChI=1S/C16H12ClF3N2O/c17-12-3-1-2-10(6-12)8-22-9-11-7-13(23-16(18,19)20)4-5-14(11)15(22)21/h1-7,21H,8-9H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at NMDA NR2B receptor assessed as calcium flux				Bioorg Med Chem Lett 17: 3997-4000 (2007) Article DOI: 10.1016/j.bmcl.2007.04.084 BindingDB Entry DOI: 10.7270/Q21J99GV
					More data for this Ligand-Target Pair