BDBM50212747 (E)-1-(4-((5,6-dimethoxy-2-oxoindolin-3-ylidene)methyl)phenyl)-3-(4-hydroxyphenyl)urea::CHEMBL396098
SMILES: COc1cc2NC(=O)\C(=C\c3ccc(NC(=O)Nc4ccc(O)cc4)cc3)c2cc1OC
InChI Key: InChIKey=WXRHMJVNURARCX-YBFXNURJSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50212747 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50212747
((E)-1-(4-((5,6-dimethoxy-2-oxoindolin-3-ylidene)me...)Show SMILES COc1cc2NC(=O)\C(=C\c3ccc(NC(=O)Nc4ccc(O)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H21N3O5/c1-31-21-12-18-19(23(29)27-20(18)13-22(21)32-2)11-14-3-5-15(6-4-14)25-24(30)26-16-7-9-17(28)10-8-16/h3-13,28H,1-2H3,(H,27,29)(H2,25,26,30)/b19-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
National Tsing Hua University
Curated by ChEMBL
| Assay Description Inhibition of RET kinase |
Bioorg Med Chem Lett 21: 4490-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.003 BindingDB Entry DOI: 10.7270/Q2BV7H06 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50212747
((E)-1-(4-((5,6-dimethoxy-2-oxoindolin-3-ylidene)me...)Show SMILES COc1cc2NC(=O)\C(=C\c3ccc(NC(=O)Nc4ccc(O)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H21N3O5/c1-31-21-12-18-19(23(29)27-20(18)13-22(21)32-2)11-14-3-5-15(6-4-14)25-24(30)26-16-7-9-17(28)10-8-16/h3-13,28H,1-2H3,(H,27,29)(H2,25,26,30)/b19-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano
Curated by ChEMBL
| Assay Description Inhibition of RET in mouse NIH3T3MEN2A cells |
Bioorg Med Chem Lett 17: 3962-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.091 BindingDB Entry DOI: 10.7270/Q2HH6JSN |
More data for this Ligand-Target Pair | |