BDBM50212748 3-(4-hydroxybenzylidene)-5,6-dimethoxyindolin-2-one::CHEMBL391567
SMILES: COc1cc2NC(=O)\C(=C\c3ccc(O)cc3)c2cc1OC
InChI Key: InChIKey=JGSMCYNBVCGIHC-NTUHNPAUSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50212748 (3-(4-hydroxybenzylidene)-5,6-dimethoxyindolin-2-on...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano Curated by ChEMBL | Assay Description Inhibition of RET in mouse NIH3T3MEN2A cells | Bioorg Med Chem Lett 17: 3962-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.091 BindingDB Entry DOI: 10.7270/Q2HH6JSN | |||||||||||
More data for this Ligand-Target Pair |