BDBM50212752 (E)-N-(4-((5,6-dimethoxy-2-oxoindolin-3-ylidene)methyl)phenyl)-4-methylpiperazine-1-carboxamide::CHEMBL247713

SMILES: COc1cc2NC(=O)\C(=C\c3ccc(NC(=O)N4CCN(C)CC4)cc3)c2cc1OC

InChI Key: InChIKey=XEQFBGHRXXOZOP-LDADJPATSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212752   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50212752 ((E)-N-(4-((5,6-dimethoxy-2-oxoindolin-3-ylidene)me...) Show SMILES COc1cc2NC(=O)\C(=C\c3ccc(NC(=O)N4CCN(C)CC4)cc3)c2cc1OC Show InChI InChI=1S/C23H26N4O4/c1-26-8-10-27(11-9-26)23(29)24-16-6-4-15(5-7-16)12-18-17-13-20(30-2)21(31-3)14-19(17)25-22(18)28/h4-7,12-14H,8-11H2,1-3H3,(H,24,29)(H,25,28)/b18-12+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Università di Milano Curated by ChEMBL					Assay Description Inhibition of RET in mouse NIH3T3MEN2A cells				Bioorg Med Chem Lett 17: 3962-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.091 BindingDB Entry DOI: 10.7270/Q2HH6JSN
					More data for this Ligand-Target Pair