Search and Browse
Download
Enter Data
BDBM50213119 (R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-benzenediol::CHEMBL229620::US10617654, Compound (R)-7::US10925840, Compound (R)-7::US9492405, (R)-7::US9492405, 25
SMILES: O[C@@H](CNCCc1ccccc1)c1cc(O)cc(O)c1
InChI Key: InChIKey=IQFFDUZWXIAVOU-INIZCTEOSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.05E+4 | -6.31 | n/a | n/a | n/a | n/a | n/a | 7.8 | 4 |
The United States of America, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988).... | US Patent US9492405 (2016) BindingDB Entry DOI: 10.7270/Q2CJ8CBM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor expressed in HEK293 cells | J Med Chem 50: 2903-15 (2007) Article DOI: 10.1021/jm070030d BindingDB Entry DOI: 10.7270/Q2R2112T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.25E+4 | -5.54 | n/a | n/a | n/a | n/a | n/a | 7.8 | 4 |
The United States of America, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988).... | US Patent US9492405 (2016) BindingDB Entry DOI: 10.7270/Q2CJ8CBM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Displacement of [3H]CGP-12177 from beta-1 adrenergic receptor in Sprague-Dawley rat cortical membrane | J Med Chem 50: 2903-15 (2007) Article DOI: 10.1021/jm070030d BindingDB Entry DOI: 10.7270/Q2R2112T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.05E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The USA, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description Twenty-four hours after adenoviral infection with human β2-AR, HEK293 cells were harvested in lysis buffer, Tris-HCl [5 mM, pH 7.4] containing E... | US Patent US10925840 (2021) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.05E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The USA, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w... | US Patent US10617654 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic recepto (Mus musculus) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.25E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The USA, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description β1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988... | US Patent US10617654 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.25E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The USA, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description Twenty-four hours after adenoviral infection with human β2-AR, HEK293 cells were harvested in lysis buffer, Tris-HCl [5 mM, pH 7.4] containing E... | US Patent US10925840 (2021) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a |
The USA, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w... | US Patent US10617654 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50213119 ((R)-(-)-5-(1-hydroxy-2-phenethylaminoethyl)-1,3-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | 7.7 | n/a |
The United States of America, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer... | US Patent US9492405 (2016) BindingDB Entry DOI: 10.7270/Q2CJ8CBM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
