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BDBM50213739 7-chloro-3-cyclopentylamino-1,1-dioxo-1,4-dihydro-1lambda6-benzo[1,2,4]thiadiazin-5-ol::CHEMBL233552

SMILES: Oc1cc(Cl)cc2c1N=C(NC1CCCC1)NS2(=O)=O

InChI Key: InChIKey=LNGVBGYRFRMOBK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50213739   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50213739
PNG
(7-chloro-3-cyclopentylamino-1,1-dioxo-1,4-dihydro-...)
Show SMILES Oc1cc(Cl)cc2c1N=C(NC1CCCC1)NS2(=O)=O |t:9|
Show InChI InChI=1S/C12H14ClN3O3S/c13-7-5-9(17)11-10(6-7)20(18,19)16-12(15-11)14-8-3-1-2-4-8/h5-6,8,17H,1-4H2,(H2,14,15,16)
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PC sid
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Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPR


Bioorg Med Chem Lett 17: 3864-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.011
BindingDB Entry DOI: 10.7270/Q21C1WKG
More data for this
Ligand-Target Pair